Found two new genetic variants associated with Alzheimer

A multicenter study is published today in JAMA has identified two genes that may be risk factors for development of Alzheimer’s disease late onset, although not help quantify the risk in carriers of these alterations.

Researchers at Boston University, U.S., in collaboration with scientists from the Rotterdam Study, coordinated by Monique Breteler, the Cardiovascular Health Study, led by Oscar Lopez, AGES-Reykjavik study, coordinated by Lenore Launer, the study in May AD , directed by Steve Younkin, the European Consortium of Alzheimer’s Disease, who leads Philippe Amouyel, the ACE Foundation in Barcelona, coordinated by Merce Boada, and the Consortium for Genetic and Environmental Risk of Alzheimer’s Disease, directed by Julie Williams, have identified two genes that may be risk factors for developing Alzheimer’s disease late onset.

The work, published today in The Journal of the American Medical Association, was carried out by analysis of genome wide association. The researchers have identified two new genes in specific locations in DNA. These genes appear to be independent of those already established by its association with the disease of Alzheimer’s, such as apolipoprotein E (APOE).

The first is located near a gene called BIN1 on chromosome 2, while the second gene is located near several genes as EXOC3L2, BLOC1S3 and mark4 on chromosome 19. “The identification of these new genes points to new biological pathways involved in the development of Alzheimer’s disease. Despite the benefits will probably be within a decade, to examine these pathways could lead to new ways to postpone, and perhaps avoid treat neurodegenerative diseases, “said Sudha Seshadri, a researcher at the Framingham Heart Study.

For its part, Breteler, of University Medical Center Rotterdam, the Netherlands, has warned that “these findings were replicated in an independent population, noting that the locations found not improve the quantification of risk of AD. The value of these is that associations could provide findings on the pathophysiological mechanisms of Alzheimer’s disease. ”

Family history
In an accompanying editorial, Nancy L. Pedersen of the Karolinska Institute in Stockholm (Sweden), says that this multicenter study points out that family history is of great importance, including Alzheimer’s disease late onset. “Today the world population faces an increased prevalence Alzheimer’s disease because life expectancy has risen past 75 years.

Findings like this reinforce the limited utility of individual genetic profiles for Alzheimer’s and lead us to collect information on age, sex, and family history and APOE status. “

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